Diarrhea is a common side effect for people taking semaglutide, with studies showing that up to 20% of patients experience this issue during therapy. While the exact cause isn’t fully understood, diarrhea from semaglutide is usually self-limited and tends to resolve over time. Experts believe that multiple factors contribute to diarrhea in semaglutide therapy, so finding the best way to manage it may require a combination of approaches. Here are some general tips to help manage symptoms.
1. Consider Dietary Adjustments
Lactose: Many people find that reducing or avoiding lactose, which is found in milk and dairy products, helps with diarrhea. This can be especially useful if you are lactose intolerant or have trouble digesting dairy products
FODMAPs: Try limiting FODMAPs (fermentable oligosaccharides, disaccharides, monosaccharides, and polyols). These are types of carbohydrates that are difficult for some people to digest, which can lead to symptoms like gas, bloating, and diarrhea. Foods high in FODMAPs include:
Certain fruits like apples, pears, and watermelon
Vegetables such as onions, garlic, and cauliflower
Sweeteners like high fructose corn syrup and sugar alcohols (e.g., sorbitol)
Dairy products for those who are lactose intolerant
Limiting these foods, even temporarily, may help reduce diarrhea while on semaglutide.
2. Hydrated:
Diarrhea can lead to dehydration, so be sure to drink plenty of fluids. Consider an electrolyte solution or a sports drink to help replenish lost minerals and prevent dehydration.
3. Small, Frequent Meals
Eating smaller, more frequent meals rather than large portions can sometimes ease gastrointestinal symptoms, giving your digestive system a chance to adjust more gradually.
4. Monitor Symptoms & Know When to Seek Help:
While diarrhea on semaglutide typically improves with time, some symptoms may need medical attention. You should contact your doctor if you experience:
Severe or persistent diarrhea that doesn’t improve over time
Fever
Blood in your stool
Signs of dehydration, such as dizziness or decreased urination
Remember that everyone’s response to semaglutide can be different. If your symptoms continue or worsen, your healthcare provider can work with you to explore alternative approaches or adjustments to your treatment.
